Ovarian sensitivity index is strongly related to circulating AMH and may be used to predict ovarian response to exogenous gonadotropins in IVF

نویسندگان

  • Valentina Biasoni
  • Ambra Patriarca
  • Paola Dalmasso
  • Angela Bertagna
  • Chiara Manieri
  • Chiara Benedetto
  • Alberto Revelli
چکیده

BACKGROUND Serum anti-Mullerian hormone (AMH) is currently considered the best marker of ovarian reserve and of ovarian responsiveness to gonadotropins in in-vitro fertilization (IVF). AMH assay, however, is not available in all IVF Units and is quite expensive, a reason that limits its use in developing countries. The aim of this study is to assess whether the "ovarian sensitivity index" precisely reflects AMH so that this index may be used as a surrogate for AMH in prediction of ovarian response during an IVF cycle. METHODS AMH serum levels were measured in 61 patients undergoing IVF with a "long" stimulation protocol including the GnRH agonist buserelin and recombinant follicle-stimulating hormone (rFSH). Patients were divided into four subgroups according to the percentile of serum AMH and their ovarian stimulation was prospectively followed. Ovarian sensitivity index (OSI) was calculated dividing the total administered FSH dose by the number of retrieved oocytes. RESULTS AMH and OSI show a highly significant negative correlation (r = -0.67; p = 0.0001) that is stronger than the one between AMH and the total number of retrieved oocytes and than the one between AMH and the total FSH dose. CONCLUSIONS OSI reflects quite satisfactory the AMH level and may be proposed as a surrogate of AMH assay in predicting ovarian responsiveness to FSH in IVF. Being very easy to calculate and costless, its use could be proposed where AMH measurement is not available or in developing countries where limiting costs is of primary importance.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Dexamethasone As a Supplement for Exogenous Gonadotropin to Improve Ovarian Response of Women over 35 Years Undergoing IVF/ICSI Cycles

Background With aging, the ovarian reserve is decreased and that is a major contributor to poor ovarian response to exogenous gonadotropins. The aim of the present study is to evaluate the role of Dexamethasone on ovarian response in infertile patients aged over 35 years undergoing IVF/ICSI cycles. MaterialsAndMethods In this triple blind placbo-control clinical trial study, a total of 72 infer...

متن کامل

O-28: Anti-Mullerian Hormone and 3D-Power Doppler Histogram: Markers of Ovarian Function with In vitro Fertilization Treatment

Background: The aim of this study was to investigate the ability of three-dimensional (3D) ultrasonography and anti-Mullerian hormone (AMH) to predict successful embryo development in patients undergoing in vitro fertilization (IVF) treatment. Materials and Methods: We prospectively studied 28 patients undergoing IVF treatment, using 3D ultrasound Sono automatic volume calculation (AVC) and a 3...

متن کامل

I-24: Individualized Controlled Ovarian Stimulation (iCOS)

Background: With the recent development of recombinant gonadotropins (FSH and LH), it has become possible to further adjust the stimulation protocol according to the expected needs of the patient. In this respect, the possible beneficial role of exogenous LH activity supplementation for stimulated ART cycles has received increasing attention. According to the two-cell, two- gonadotropin theory,...

متن کامل

Pnm-5: Anti-Mullerian Hormone in The Assessment and follow up of Cancer in Young Females

Background The impact of cancer therapy on the reproductive potential of patients is increasingly recognized because survival rates of patients have clearly improved in recent years. The study stressed the use of AMH may allow better prediction of chemotherapy-related risk to further fertility. MaterialsAndMethods A narrative review was performed within articles published at PubMed, Elsevier, S...

متن کامل

P-210: Evaluation of Anti-FSH Antibodies Levels as A Prognostic Marker in IVF Outcome

Background: The objective of this study is to establish importance of anti-FSH antibodies in IVF outcome. Materials and Methods: This research was designed based on evaluation of several articles from 2000 till 2012 about anti-FSH antibodies in IVF outcome. Results: Serum concentrations of anti-FSH IgG and IgA were linearly associated with poorer ovarian stimulation outcome. For example 1.0 AU ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2011